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Synthesis of analogs of the ergot alkaloids

✍ Scribed by Lucjan Strekowski; Koen Van Aken; Yuri Gulevich


Publisher
Journal of Heterocyclic Chemistry
Year
2000
Tongue
English
Weight
392 KB
Volume
37
Category
Article
ISSN
0022-152X

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✦ Synopsis


Abstract

A number of 3,4,5,6‐tetrahydro‐1__H__‐azepino[5,4,3‐cd]indole derivatives have been synthesized starting with methyl indole‐4‐carboxylate functionalized at the 3 position.


πŸ“œ SIMILAR VOLUMES


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Studies of the effect of xanthines on the solubility of molecules related to the proteinaceous ergot alkaloids indicate the indole moiety to be a primary site for complexation. The tendency of indole and several analogs to form intermolecular complexes with caffeine was surveyed. This property leads