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An unstructured kinetic model of macromolecular metabolism in batch and fed-batch cultures of hybridoma cells producing monoclonal antibody

✍ Scribed by Jae Deog Jang; John P. Barford

Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
427 KB
Volume
4
Category
Article
ISSN
1369-703X

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## Abstract Genome‐scale modeling of mouse hybridoma cells producing monoclonal antibodies (mAb) was performed to elucidate their physiological and metabolic states during fed‐batch cell culture. Initially, feed media nutrients were monitored to identify key components among carbon sources and amin