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An oral oligonucleotide delivery system based on a thiolated polymer: Development and in vitro evaluation

✍ Scribed by Ronny Martien; Herbert Hoyer; Glen Perera; Andreas Bernkop Schnürch


Book ID
116438441
Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
390 KB
Volume
78
Category
Article
ISSN
0939-6411

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The aim of this study was the preparation and in vivo evaluation of a nasal insulin delivery system based on thiolated chitosan. 2-Iminothiolane was covalently attached to chitosan. The resulting conjugate (chitosan-TBA) exhibited 304.9 +/- 63.5 micromol thiol groups per gram polymer. Microparticles