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In VivoEvaluation of an Oral Salmon Calcitonin-Delivery System Based on a Thiolated Chitosan Carrier Matrix

✍ Scribed by Davide Guggi; Constantia E. Kast; Andreas Bernkop-Schnürch

Book ID
111603472
Publisher
Springer US
Year
2003
Tongue
English
Weight
87 KB
Volume
20
Category
Article
ISSN
0724-8741

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✍ Alexander H. Krauland; Verena M. Leitner; Vjera Grabovac; Andreas Bernkop-Schnür 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 172 KB

The aim of this study was the preparation and in vivo evaluation of a nasal insulin delivery system based on thiolated chitosan. 2-Iminothiolane was covalently attached to chitosan. The resulting conjugate (chitosan-TBA) exhibited 304.9 +/- 63.5 micromol thiol groups per gram polymer. Microparticles