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An integrated chemoenzymatic synthesis of enantiopure (−)-(1R,5S)-cyclosarkomycin: a sarkomycin precursor

✍ Scribed by Laura Andrau; Jacques Lebreton; Pascale Viazzo; Véronique Alphand; Roland Furstoss

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
135 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

A five-step chemoenzymatic synthesis of (-)-(1R, SS)-cyclosarkomycin 2 has been achieved starting from commercial racemic bicycloheptenone 3. The strategy developed involved -as key stepsan enantioselective microbiologically catalyzed Baeyer-Villiger oxidation followed by a chemical regioselective epoxide ring opening.

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