An in vitro assessment of the antineoplastic potential of 2H-1,3-Oxazine-2,6(3H)-dione (3-oxauracil), a novel pyrimidine
β Scribed by Lawton Seal; Daniel Von Hoff; Richard Lawrence; Elzbieta Izbicka; Richard M. Jamison
- Book ID
- 110230844
- Publisher
- Springer US
- Year
- 1997
- Tongue
- English
- Weight
- 65 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0167-6997
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## Abstract A rapid simple method for the typing of wild HSV isolates based on selective inhibition of HSVβ2 replication by the pyrimidine analogue oxauracil (2Hβ1,3βoxazineβ2,6(3H)βdione) has been developed. Chiβsquare analysis of the results of typing of 30 wild strains by serum neutralization te
Treatment of suckling mice with the pyrimidine analogue 2H-1,3-oxazine-2,6(3H)-dione (oxauracil) proved successful in reducing mortality associated with HSV-2-induced encephalitis. Oxauracil did not decrease mortality associated with HSV-1 infection; however, there was an increased survival time and
We have recently shown' that 2,3-dfhydro-1,3-6H-oxaxine-2,6-dione (l), the oxaatne analog of