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Evaluation of the effectiveness of 2H-1, 3-Oxazine-2,6(3H)-dione (Oxauracil) in the treatment of herpes simplex virus (HSV)-Induced acute encephalitis in mice

✍ Scribed by Lawton A. Seal; Richard M. Jamison

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
292 KB
Volume
13
Category
Article
ISSN
0146-6615

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✦ Synopsis

Treatment of suckling mice with the pyrimidine analogue 2H-1,3-oxazine-2,6(3H)-dione (oxauracil) proved successful in reducing mortality associated with HSV-2-induced encephalitis. Oxauracil did not decrease mortality associated with HSV-1 infection; however, there was an increased survival time and a decrease in the amount of infectious virus recovered from the brains of HSV-1-infected animals.

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