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An improved synthesis of the strained pyrrolidine-5,5-translactam ring system

✍ Scribed by Alan D. Borthwick; Andy Crame; Anne Exall; Andy Mason; Andy Pennell

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
119 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

An improved synthesis of the 5-Oxo-hexahydro-pyrrolo[3,2-b]pyrrole ring system (Pyrrolidine-5,5trans-lactam ring system) has been achieved using cyclisation of the amino ethyl ester 4 with t-butyl magnesium chloride in THF to give the translactam 5 in 78% yield

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ChemInform Abstract: Stereoselective Syn
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Reduction of the indole ring system: syn
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