✦ LIBER ✦

An improved synthesis of the broad spectrum matrix metalloprotease inhibitor marimastat

✍ Scribed by Richard J Davenport; Robert J Watson

Book ID: 104210927
Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 65 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)01376-9

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✦ Synopsis

A considerably shortened synthesis of the broad spectrum matrix metalloproteinase (MMP) inhibitor marimastat has been achieved by a direct hydroxylamino ring opening of a key acetonide intermediate.

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