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An Improved Synthesis of the Selective Matrix Metalloproteinase Inhibitor, Ro 28-2653

✍ Scribed by Daniewski, Andrzej R.; Liu, Wen; Okabe, Masami


Book ID
125960455
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
65 KB
Volume
8
Category
Article
ISSN
1083-6160

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An improved synthesis of the broad spect
✍ Richard J Davenport; Robert J Watson πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 65 KB

A considerably shortened synthesis of the broad spectrum matrix metalloproteinase (MMP) inhibitor marimastat has been achieved by a direct hydroxylamino ring opening of a key acetonide intermediate.