Application of epimerisation-free amide coupling conditions to the synthesis of matrix metalloprotease inhibitor intermediates

ChemInform Abstract: Application of Epim

ChemInform Abstract: Application of Epimerization-Free Amide Coupling Conditions to the Synthesis of Matrix Metalloprotease Inhibitor Intermediates.

✍ M. J. FRAY; D. ELLIS 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB

Application of Epimerization-Free Amide Coupling Conditions to the Synthesis of Matrix Metalloprotease Inhibitor Intermediates. -The tert-leucine derivative (I) is successfully coupled with a variety of amines to give peptides in good to excellent yields with minimal epimerization at the tert-leuci