~-2'-Deoxy-[9,amino-~~N~Jadenosine has been synthesized in 4 steps from commercially available 5-amino-4,6-dichloropyrimidine and 15NH3.
An improved synthesis of [amino-15N]adenine; useful in the large scale synthesis of 2′-deoxy[amino-15N]adenosine
✍ Scribed by Joe Kelly; David A. Ashburn; Ryszard Michalczyk; Louis A. Silks III
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- French
- Weight
- 259 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
2′‐Deoxy[Amino‐^15^N]Adenosine has been constructed in two steps from commercially available starting materials. These reactions have been scaled up to give 5 gram lots of labeled material.
📜 SIMILAR VOLUMES
~-2'-Deoxy-[9,Amino-~~N~]Adenosine has been constructed in 4 steps from commercially available 5-amino-4,6-dichloropyrirnidine and 15NH3. The reactions have been scaled to provide significant quantities of labeled nucleoside.
## Abstract We have reinvestigated the synthesis of [^15^N~2~]hydroxymethyl imidazole from dihydroxyacetone, formaldehyde, and labelled ammonia in an attempt to optimize the yield from the isotope. Conversion of the hydroxymethyl imidazole to histidine was accomplished in good yield without the nee
Using 1 -chloro-l-[~~N]nitrosocyclohexane, we have prepared five L-[a-'SN]arnino acids. The stereoselective electophillic hydroxyamination of (S)-acylbornane-l0,2-suftams, followed by ZnO/H+ reduction, and alkaline cleavage of the chiral auxiliary, gave the amino acids in 97.2-99.5 % e.e. By starti
## Abstract The synthesis of 2‐amino‐3‐([^15^N]‐methylamino)propanoic acid (synonyms, BMAA, β‐N‐methylamino‐alanine) from α‐acetamidoacrylic acid and [^15^N]‐methylamine is described. Enantioselective hydrolysis of the acetamide group, mediated by the enzyme Acylase 1 (EC 3.5.1.14), yielded (R)‐BMA
An Improved Large Scale Synthesis of 2-Amino-4-chloropyridine and Its Use for the Convenient Preparation of Various Polychlorinated 2-Aminopyridines. -An efficient large scale synthesis of 2-amino-4-chloropyridine (IV) and its conversion into the hitherto not described dichloropyridine (V) as well