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A reinvestigation of the synthesis of [15N2]hydroxymethylimidazole: Useful in an improved synthesis of (D,L)-[τ,π-15N2]histidine

✍ Scribed by Louis A. Silks III; Erik Dunkle; Clifford J. Ünkefer; James L. Sudmeier; Michael Butler; William W. Bachovchin

Publisher: John Wiley and Sons
Year: 1995
Tongue: French
Weight: 297 KB
Volume: 36
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580361006

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✦ Synopsis

Abstract

We have reinvestigated the synthesis of [^15^N~2~]hydroxymethyl imidazole from dihydroxyacetone, formaldehyde, and labelled ammonia in an attempt to optimize the yield from the isotope. Conversion of the hydroxymethyl imidazole to histidine was accomplished in good yield without the need for picric acid as an ion pairing agent.

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.