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An improved synthesis of [5′-3H]-3′-azido-3′-deoxythymidine, tritiated zidovudine

✍ Scribed by John A. Hill; G. Andrew Freeman

Publisher
John Wiley and Sons
Year
1988
Tongue
French
Weight
152 KB
Volume
25
Category
Article
ISSN
0022-2135

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✦ Synopsis

S'-W]-3'-Azid~3'dcoxythymidinc @) was prepared at a specific activity of 14.0 Cilmmol by a twestep synthetic sequence involving controlled oxidation of the unlabelled compound c1) to the 5'-aldehyde (1) fdlowed by reduction with (W]-NaBH.. Purification was performed by preparative TLC. The radiochemical purity was 99.2%.

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