𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Improved and Reliable Synthesis of 3′-Azido-2′,3′-dideoxyguanosine Derivatives

✍ Scribed by Victor A. Timoshchuk; Richard I. Hogrefe; Morteza M. Vaghefi

Publisher
John Wiley and Sons
Year
2004
Weight
135 KB
Volume
35
Category
Article
ISSN
0931-7597

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Synthesis of 2′-Azido-2′,3′-didehydro-2′
Synthesis of 2′-Azido-2′,3′-didehydro-2′,3′-dideoxythymidine
✍ Mikhailopulo, Igor A. ;Zaitseva, Galina V. ;Vaaks, Elena V. ;Balzarini, Jan ;De 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 598 KB

## Abstract Compound 15 – the 2′‐azido analog of the anti‐HIV compound 2′,3′‐didehydro‐2′,3′‐dideoxythymidine – was synthesized. Treatment of 5′‐__O__‐trityl‐β‐D‐ribofuranosylthymine (1) with DAST or MSTF gave the 2,2′‐anhydro derivative 2. The latter and its 3′‐__O__‐benzoate 3 were used for the s

An improved synthesis of [5′-3H]-3′-azid
An improved synthesis of [5′-3H]-3′-azido-3′-deoxythymidine, tritiated zidovudine
✍ John A. Hill; G. Andrew Freeman 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 French ⚖ 152 KB

S'-W]-3'-Azid~3'dcoxythymidinc @) was prepared at a specific activity of 14.0 Cilmmol by a twestep synthetic sequence involving controlled oxidation of the unlabelled compound c1) to the 5'-aldehyde (1) fdlowed by reduction with (W]-NaBH.. Purification was performed by preparative TLC. The radiochem

Synthesis of tritium-labelled 3′-azido-3
Synthesis of tritium-labelled 3′-azido-3′-deoxythymidine
✍ G.V. Sidorov; Yu.B. Zverkov; N.F. Myasoedov; M.V. Jasko; Yu.S. Skoblov 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 97 KB

## Abstract New approaches to the synthesis of 3′‐azido‐3′‐deoxythymidine labelled with tritium in the heterocyclic base have been developed. With this aim, enzymatic transribosylation with [^3^H]thymine using the enzyme preparation from rat liver and a three‐step chemical synthesis with use of the

Synthesis of 3′-azido-2′,3′-dideoxy-β-D-
Synthesis of 3′-azido-2′,3′-dideoxy-β-D-arabino-hexopyranosyl nucleosides
✍ Hansen, Poul ;Lau, Jesper ;Pedersen, Erik B. ;Nielsen, Carsten M. 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 439 KB

## Abstract The α,β‐unsaturated D‐sugar aldehyde 2, prepared from tri‐__O__‐acetyl‐D‐glucal, was converted into 1‐__O__‐acetyl‐3‐azido‐2,3‐dideoxy‐α‐D‐__arabino__‐pyranose (3) by reaction with sodium azide in a mixture of acetic acid and water followed by acetylation. Reaction of 3 with silylated p