[2‐^14^ C]2,5‐dichloropyrimidine is a useful reagent for labeling biologically active compounds for use in hepatocyte transport studies, protein covalent binding, and metabolic profiling. This paper describes a novel five‐step synthesis of [2‐^14^ C]2,5‐dichloropyrimidine from readily available [^14
An improved synthesis of [2-14C]2, 5-dichloropyrimidine
✍ Scribed by Kai Cao; Scott B. Tran; Brad D. Maxwell; Samuel J. Bonacorsi Jr.
- Book ID
- 112132932
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- French
- Weight
- 339 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0022-2135
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## Abstract Diethyl ethoxymethylenemalonate was condensed with thiourea−^14^C in the presence of sodium ethylate to give ethyl 2‐thio‐6‐oxypyrimidine‐5‐carboxylate‐2−^14^C. Desulfurization of the latter pyrimidine with chloroacetic acid gave uracil‐5‐carboxylic acid‐2−^14^C, which was subsequently
## Abstract A convenient synthesis of the pharmacological intermediate 2‐pyrrolidione‐5‐^14^C, was developed using potassium cyanide ^14^C as starting material. Potassim cyanide‐^14^C was converted to 2‐pyrrolidinone‐5‐^14^C in an overall 56% radiochemical yield.