Specifically labelled phenylacetic acid and mandelic acid derivatives, metabolites of L-Dopa, have been synthesized via the intermediary labelled benzyl alcohols, which were prepared by reduction of the methyl esters of the appropriate benzoic acids. The benzyl alcohols have been converted to the co
An improved synthesis of [1-14C]-labelled 2-butynedioic acid, succinic acid and succinyl chloride
โ Scribed by Vijayalakshmi V. Somayaji; Tse W. Hall; Leonard I. Wiebe; Edward E. Knaus
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- French
- Weight
- 236 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0022-2135
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## Abstract Efficient carbonโ14 labeling of four potent and selective DP1 antagonists is reported. The synthetic sequence began with ฮฑโhydroxylation, reduction of an ester, followed by oxidative diol cleavage and aldehyde reduction. The resulting alcohol **4** was converted to a mesylate then nucle
## Abstract D,Lโ2,6โDiaminopimelicโ(2โ^14^C) acid was prepared by alkylation of diethyl acetamidomalonateโ(2โ^14^C) with 5โbromoโNโphthaloylโLโnorvaline methyl ester and hydrolysis of the condensation product. Depending on the alkylation conditions, partial or complete racemisation takes place and