An expeditious synthesis of epibatidine and analogues
β Scribed by Ganesh Pandey; Trusar D. Bagul; G. Lakshmaiah
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- French
- Weight
- 221 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0040-4039
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Brominalion and bromoh)drox)lalion of oxazolidinones derived from cyclohexadienc have been studied in order to synlhctizc (\_+)-cpibatidine 18. Bromohydrox.wlation of compound 2 led to a polyfunctionalized halohydrin lla ~vhich could be furlher c.vclized to azabieyclol2.2. I Iheptan-2one 16 already
Conformationally constrained spirofuropyridine analogues of epibatidine, syn-2 and anti-2, in which the 7-azabicyclo[2.2.1]heptane system and the 2-chloropyridine ring are held rigidly with the shorter and longer N-N distances, respectively, were synthesized from N-Boc-7-azabicyclo[2.2.1]heptan-2-on
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