An expedient synthesis of ellipticine via Suzuki–Miyaura coupling

✍ Scribed by Takeo Konakahara; Y.B. Kiran; Yuri Okuno; Reiko Ikeda; Norio Sakai

• Book ID: 104097549
• Publisher: Elsevier Science
• Year: 2010
• Tongue: French
• Weight: 269 KB
• Volume: 51
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.02.125

✦ Synopsis

A simple and efficient total synthesis of ellipticine was developed via the Suzuki-Miyaura coupling of sterically sensitive 2-hydroxybenzeneboronic acid with a multifunctional aryl halide using Pd(OAc) 2 as a catalyst and Cu(OAc) 2 ÁH 2 O as an additive in DMSO/H 2 O as a key step followed by double N-arylation and cyclization.