✦ LIBER ✦

An exception of eschweiler-clarke methylation: Cyclocondensation of α-amino amides with formaldehyde and formic acid

✍ Scribed by Fu-Lin Chen; Kuangsen Sung

Publisher: Journal of Heterocyclic Chemistry
Year: 2004
Tongue: English
Weight: 172 KB
Volume: 41
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570410507

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

An exception of Eschweiler‐Clarke methylation was found for α‐amino amides. The α‐amino amides on treatment with formaldehyde and formic acid produce cyclocondensation products, imidazolidin‐4‐ones, but N‐methylation process becomes important when three substituents of the α‐amino amides are very bulky. On the other hand, N‐methylation is the only product for Eschweiler‐Clarke methylation of the α‐amino amides with N,N‐disubstituted amide.

📜 SIMILAR VOLUMES

An Exception of Eschweiler-Clarke Methyl

An Exception of Eschweiler-Clarke Methylation: Cyclocondensation of α-Amino Amides with Formaldehyde and Formic Acid.

✍ Fu-Lin Chen; Kuangsen Sung 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 17 KB

ChemInform Abstract: Synthesis of N-(Ami

ChemInform Abstract: Synthesis of N-(Amidomethyl)- and N-(Imidomethyl)-α-amino Acid Esters by Reaction of α-Amino Acid Esters with Formaldehyde and Amides or Imides

✍ S. G. ZLOTIN; I. V. SHAROVA; O. A. LUK'YANOV 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 1 views

Copper-Catalyzed Asymmetric Michael Reac

Copper-Catalyzed Asymmetric Michael Reactions with α-Amino Acid Amides: Synthesis of an Optically Active Piperidine Derivative

✍ Jens Christoffers; Heiko Scharl 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 234 KB 👁 1 views