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Copper-Catalyzed Asymmetric Michael Reactions with α-Amino Acid Amides: Synthesis of an Optically Active Piperidine Derivative

✍ Scribed by Jens Christoffers; Heiko Scharl

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
234 KB
Volume
2002
Category
Article
ISSN
1434-193X

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## Abstract **Two activations are better than one**: The chiral bifunctional guanidine **1**, which features an amino amide backbone, catalyzes the asymmetric Michael addition of a range of substrates and gives products with excellent stereoselectivities. The method also allows the efficient synthe