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Bifunctional Guanidine via an Amino Amide Skeleton for Asymmetric Michael Reactions of β-Ketoesters with Nitroolefins: A Concise Synthesis of Bicyclic β-Amino Acids

✍ Scribed by Zhipeng Yu; Xiaohua Liu; Lin Zhou; Lili Lin; Xiaoming Feng

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
196 KB
Volume
121
Category
Article
ISSN
0044-8249

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Bifunctional Guanidine via an Amino Amid
Bifunctional Guanidine via an Amino Amide Skeleton for Asymmetric Michael Reactions of β-Ketoesters with Nitroolefins: A Concise Synthesis of Bicyclic β-Amino Acids
✍ Zhipeng Yu; Xiaohua Liu; Lin Zhou; Lili Lin; Xiaoming Feng 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 445 KB

## Abstract **Two activations are better than one**: The chiral bifunctional guanidine **1**, which features an amino amide backbone, catalyzes the asymmetric Michael addition of a range of substrates and gives products with excellent stereoselectivities. The method also allows the efficient synthe