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An Exception of Eschweiler-Clarke Methylation: Cyclocondensation of α-Amino Amides with Formaldehyde and Formic Acid.

✍ Scribed by Fu-Lin Chen; Kuangsen Sung


Publisher
John Wiley and Sons
Year
2005
Weight
17 KB
Volume
36
Category
Article
ISSN
0931-7597

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An exception of eschweiler-clarke methyl
✍ Fu-Lin Chen; Kuangsen Sung 📂 Article 📅 2004 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 172 KB

## Abstract An exception of Eschweiler‐Clarke methylation was found for α‐amino amides. The α‐amino amides on treatment with formaldehyde and formic acid produce cyclocondensation products, imidazolidin‐4‐ones, but __N__‐methylation process becomes important when three substituents of the α‐amino a