## Communicated by Dvorah Abeliovich Germline mutations in the BRCA1 and BRCA2 genes confer a high lifetime risk of developing breast and other cancers; however, remarkable differences exist regarding disease manifestation in mutation carriers. It has been suggested that other genetic and/or enviro
✦ LIBER ✦
An evaluation of the polymorphisms Ins16bp and Arg72Pro in p53 as breast cancer risk modifiers in BRCA1 and BRCA2 mutation carriers
✍ Scribed by Osorio, A; Pollán, M; Pita, G; Schmutzler, R K; Versmold, B; Engel, C; Meindl, A; Arnold, N; Preisler-Adams, S; Niederacher, D
- Book ID
- 109999718
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 79 KB
- Volume
- 99
- Category
- Article
- ISSN
- 0007-0920
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## Abstract Germline mutations in the BRCA1 and BRCA2 genes are associated with a significantly increased lifetime risk for developing breast and/or ovarian cancer. However, incomplete penetrance and substantial variability in age of disease onset among carriers of the same mutation suggests the in
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