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Promoter methylation patterns of ATM, ATR, BRCA1, BRCA2 and P53 as putative cancer risk modifiers in JewishBRCA1/BRCA2mutation carriers

✍ Scribed by Tair Kontorovich; Yoram Cohen; Uri Nir; Eitan Friedman


Publisher
Springer US
Year
2008
Tongue
English
Weight
276 KB
Volume
116
Category
Article
ISSN
0167-6806

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## Abstract Germline mutations in the BRCA1 and BRCA2 genes are associated with a significantly increased lifetime risk for developing breast and/or ovarian cancer. However, incomplete penetrance and substantial variability in age of disease onset among carriers of the same mutation suggests the in