An enantiospecific synthesis of a taxol A-ring building unit.
✍ Scribed by Lars Pettersson; Torbjörn Frejd; Göran Magnusson
- Book ID
- 108382967
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- French
- Weight
- 275 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
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Absfhzct. The optically active tax01 A-ring unit 3 was synthesized in 11 steps from 2-isopropyl-2-propenol. The stereogenic centers were introduced via the asymmeuic glyoxylateene reaction and the Sharpless asymmetric epoxidation reaction. The total synthesis of tax01 (1) and analogous compounds ha
A fully functionalised synthesis of taxol A-ring, through Michael/Wittig reaction and regioselective opening epoxide as key steps and also a methodology for substituted cyclohexadienes through tandem Michael/WRtig reaction is described.