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An efficient synthesis of δ-aminolevulinic acid (ALA) and its isotopomers

✍ Scribed by Jianji Wang; A.Ian Scott

Book ID
104256164
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
112 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

A new and improved synthesis of 13C-4-, 13C-5-and 15N-8-aminolevulinic acid (ALA), with 90% overall yield in 4 steps from labelled glycine, is described.

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A facile synthesis of δ-aminolevulinic a
A facile synthesis of δ-aminolevulinic acid (ALA) regioselectively labeled with 13C and direct observation of enzymatic transformation from ALA to porphobilinogen (PBG)
✍ Katsuyuki Kurumaya; Takeo Okazaki; Nobuo Seido; Yuzuru Akasaka; Yoshiki Kawajiri 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 French ⚖ 656 KB

6-Aminolevulinic acid (ALA), labeled with 3C at position 1 , 2, 3, 4 , or 5, was synthesized from 13C-labeled glycine, Meldrum's acid, or bromoacetate. The latter compounds were prepared from 3C-sodium acetate or 3C-acetic acid. Enzymatic transformation from ALA to porphobilinogen (PBG) was directl