2S,3S,4R)-4-Amino-3-hydroxy-2-methylpentanoic acid has been synthesized through acylation of a chiral enolate and subsequent stereoselective reduction.
An efficient synthesis of protected (2R,3R,4S)-4,7-diamino-2,3-dihydroxyheptanoic acid, a constituent of callipeltins A and D
β Scribed by A. Ravi Kumar; B. Venkateswara Rao
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- French
- Weight
- 152 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0040-4039
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Taking advantage of the high functionality of an enantiopure protected syn-2R-amino-l,3,4-triol derivative, easily available on a multigram scale from Disoascorbic acid, several biologically active compounds have been synthesized such as the (2S,3R)-3-amino-2-hydroxydecanoic acid (AHDA), the N-termi
An efficient synthesis of the non-proteinogenic amino acid (2R,3S)-4,4,4-trifluoro(OBn)-threonine is described. Starting with commercially available (S)-Garner's aldehyde, the desired amino acid was prepared as its hydrochloride salt in five steps and an overall yield of 33% (59% based on recovered