✦ LIBER ✦

An efficient synthesis of optically pure anthracyclinone intermediates by the novel use of microbial reduction

✍ Scribed by Shiro Terashima; Katsumi Tamoto

Publisher: Elsevier Science
Year: 1982
Tongue: French
Weight: 281 KB
Volume: 23
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)88665-7

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✦ Synopsis

Reduction of the racemic a-hydroxy ketones((?)-3&) with fermenting baker's yeast followed by fractional recrystallization and oxidation was found to readily afford optically pure anthracyclinone intermediates((R and their partially optically active antipodes ((S)(+)-m The useless enantiomers((S)(+)-m and diastereomeric viclnal-diols((+)-

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