✦ LIBER ✦

(+)- and (-)-1-0, 4-0-bis(p-chlorobenzyl)threitol as novel resolving agents for optically active anthracyclinone synthesis: an efficient synthesis of optically pure 4-demethoxydaunomycinone

✍ Scribed by Shiro Terashima; Katsumi Tamoto; Masamichi Sugimori

Publisher: Elsevier Science
Year: 1982
Tongue: French
Weight: 276 KB
Volume: 23
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)88360-4

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✦ Synopsis

Sumnary (*)-7-Deoxy-4-demethoxydaunomyclnone((f) was cleanly resolved by forming a mixture of the dlastereomenc acetals((-)-2 and (+)-12 or (+)-zand (-)-19 with the title zm-dlol((+)-or (-)-g to give optically pure (R)(-)-A The method for racemizing the undesired enantiomer((S)(+)-2) was also explored Optically pure (+)-4-demethoxydaunomycinone((t)-2b) was elaborated from (R)(-)-3_ according to the reported reaction scheme.