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An Efficient Synthesis of N-Substituted-3-aryl-3-(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-enyl)propanamides by Four-component Reaction in Aqueous Medium

✍ Scribed by Guolan Dou; Xiaoxing Zhong; Deming Wang; Daqing Shi

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
129 KB
Volume
29
Category
Article
ISSN
0256-7660

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✦ Synopsis

Abstract

A mild and efficient synthesis of N‐substituted‐3‐aryl‐3‐(2‐hydroxy‐4,4‐dimethyl‐6‐oxocyclohex‐1‐enyl)propanamides via four‐component reaction of an aldehyde, amine, Meldrum's acid and 5,5‐dimethylcyclo‐hexane‐1,3‐dione in the presence of benzyltriethylammonium chloride (TEBAC) in aqueous medium is described. This method has the advantages of accessible starting materials, good yields, mild reaction conditions and eco‐friendliness.

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