The development of an ecofriendly procedure for alkaline metal (II) sulfate promoted synthesis of N,N′-dimethyl substituted (unsubstituted)-4-aryl-3,4-dihydropyrimidones (thiones) and corresponding bis-analogues in aqueous medium: Evaluation by green chemistry metrics

✍ Scribed by Chhanda Mukhopadhyay; Arup Datta

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2010
• Tongue: English
• Weight: 155 KB
• Volume: 47
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.283

✦ Synopsis

Abstract

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Different alkaline metal (II) sulfates were used as catalysts for the N,N′‐dimethyl substituted as well as unsubstituted 4‐aryl‐3,4‐dihydropyrimidones (thiones) and their corresponding bis‐analogues in aqueous medium. Among the various salts, MgSO~4~·7H~2~O (Epsom salt) proved to be the best catalyst giving the desired products in good to excellent yields. This catalyst enables the construction of a series of compound libraries particularly for N,N′‐dimethyl substituted DHPM's whose synthesis is very rare in the literature. The reaction on a wide variety substrates was evaluated by the application of green chemistry metrics and a very good correlation was obtained. J. Heterocyclic Chem., 2010.