An efficient synthesis of glycosyl esters exploiting the mitsunobu reaction.
โ Scribed by Amos B. Smith III; Karl J. Hale; Ralph A. Rivero
- Book ID
- 104219412
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- French
- Weight
- 247 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0040-4039
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## Abstract The Mitsunobu reaction has been used as an efficient tool for the synthesis of orthogonallyโprotected and unprotected depsipeptides such as Boc/FmocโLโLys(Alloc)โDโAlaโDโLacโOAllyl or LโLysโ DโAlaโDโLac that are bacterial cell wall precursor analogues found in vancomycinโresistant enter
A wide range of commercial diazodicarboxylates and phosphines were screened in an attempt to find purification-free conditions for application in parallel synthesis. The combination of immobilized triphenylphosphine and TMAD proved to be suitable for the synthesis of aryl ethers via the Mitsunobu re