An efficient synthesis of (3R)-4-amino-3-hydroxy butyric acid (GABOB) via cyclic sulfite methodology
โ Scribed by B.B. Lohray; A. Sekar Reddy; Vidya Bhushan
- Book ID
- 108036473
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 391 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0957-4166
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๐ SIMILAR VOLUMES
## Abstract Enzymatic resolution of racemic 3โhydroxyโ4โ(tosyloxy)butanenitrile ((ยฑ)โ**5**) by using various lipases in different solvents were studied. The obtained optically pure (3__R__)โ3โ(acetyloxy)โ4โ(tosyloxy)butanenitrile ((__R__)โ**6**), upon treatment with aqueous ammonia followed by conc
2S,3S,4R)-4-Amino-3-hydroxy-2-methylpentanoic acid has been synthesized through acylation of a chiral enolate and subsequent stereoselective reduction.
## Abstract The excitatory, amino acid ยฑ2โaminoโ3โ(3โhydroxyโ5โmethylisoxazolโ4โyl)propionic acid hydrobromide was prepared in gram quantities in an 3.3% overall yield from methylbut 2โynoate. The key step was the facile preparation of methyl 3โbromoโ5โmethylisoxazoleโ4โcarboxylate.