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(2S,3S,4R)-4-Amino-3-hydroxy-2-methylvalerate. Synthesis of an amino acid constituent of bleomycin from L-rhamnose

✍ Scribed by Ohgi, Tadaaki; Hecht, Sidney M.


Book ID
126871479
Publisher
American Chemical Society
Year
1981
Tongue
English
Weight
384 KB
Volume
46
Category
Article
ISSN
0022-3263

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Synthesis of (2S,3R)-3-amino-2-hydroxyde
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Taking advantage of the high functionality of an enantiopure protected syn-2R-amino-l,3,4-triol derivative, easily available on a multigram scale from Disoascorbic acid, several biologically active compounds have been synthesized such as the (2S,3R)-3-amino-2-hydroxydecanoic acid (AHDA), the N-termi