An efficient synthesis of 3-cyano-3-benzoyloxyoxindoles via cyanoacylation of isatins in the presence of 4Å molecular sieves
✍ Scribed by Esmaeili, Abbas Ali; Ghalandarabad, Saeid Amini; Zangouei, Mahdieh
- Book ID
- 120088718
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- French
- Weight
- 371 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0040-4039
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Malononitrile has been found to be acylated effectively using N-protected glycines by simultaneous activation of an amino acid carbonyl group and a malononitrile methylene group using carbonyl diimidazole (CDI). The corresponding aminoacetonitriles were isolated as enols and/or as their tautomeric f
An Efficient Synthesis of 2-Amino-3-cyano-2-pyrrolin-4-ones, via the Corresponding Open Chain Tautomers (Aminoacetylmalononitriles). -The C-acylation of malononitrile (II) with various N-protected glycines (I) is performed using carbonyl diimidazole as condensation reagent. Depending on the protecti
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