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An Efficient Synthesis of 2-Amino-3-cyano-2-pyrrolin-4-ones, via the Corresponding Open Chain Tautomers (Aminoacetylmalononitriles).

✍ Scribed by Stylianos Hamilakis; Athanase Tsolomitis

Publisher: John Wiley and Sons
Year: 2003
Weight: 109 KB
Volume: 34
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200333119

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✦ Synopsis

An Efficient Synthesis of 2-Amino-3-cyano-2-pyrrolin-4-ones, via the Corresponding Open Chain Tautomers (Aminoacetylmalononitriles). -The C-acylation of malononitrile (II) with various N-protected glycines (I) is performed using carbonyl diimidazole as condensation reagent. Depending on the protective group the aminoacetonitriles are isolated in their open-chain form or after cyclization as 2-amino-3-cyano

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