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An efficient synthesis of 2-amino-3-cyano-2-pyrrolin-4-ones, via the corresponding open chain tautomers (aminoacetylmalononitriles)

✍ Scribed by Stylianos Hamilakis; Athanase Tsolomitis

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 125 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)00730-5

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✦ Synopsis

Malononitrile has been found to be acylated effectively using N-protected glycines by simultaneous activation of an amino acid carbonyl group and a malononitrile methylene group using carbonyl diimidazole (CDI). The corresponding aminoacetonitriles were isolated as enols and/or as their tautomeric forms, 2-amino-3-cyano-2-pyrrolin-4-ones.

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