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An efficient one-pot synthesis of pyrazolo[3,4-b]pyridinone derivatives catalyzed by L-proline

✍ Scribed by Chun-Ling Shi; Hui Chen; Da-Qing Shi

Publisher
Journal of Heterocyclic Chemistry
Year
2010
Tongue
English
Weight
120 KB
Volume
48
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

A series of 3‐methyl‐1,4‐disubstituted‐4,5‐dihydro‐1__H__‐pyrazolo[3,4‐b]pyridine‐6(7__H__)‐ones was synthesized via the three‐component reaction of aldehyde, 3‐methyl‐1‐phenyl‐1__H__‐pyrazol‐5‐amine, and Meldrum's acid catalyzed by L‐proline. This protocol has the advantages of easier work‐up, milder reaction conditions, and high yields. J. Heterocyclic Chem., (2011).

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