An efficient one-pot multicomponent synthesis of 3,4-dihydropyrimidine-2-(1H)-ones/thiones/imines via a Lewis base catalyzed Biginelli-type reaction under solvent-free conditions
β Scribed by Sheik Mansoor, S.; Syed Shafi, S.; Zaheer Ahmed, S.
- Book ID
- 121321957
- Publisher
- Elsevier
- Year
- 2016
- Tongue
- English
- Weight
- 499 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1878-5352
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## Abstract The Biginelliβtype condensation of ethyl acetoacetate/cycloketone, aldehyde and urea/thiourea under solventβfree condition catalyzed by 10% gallium(III) iodide to form dihydropyrimidineβ2(1__H__)βone derivatives was described. This process offered one way to constructing dihydropyrimidi
We report herein the use of triphenylphosphine (TPP) as a new catalyst for the one-pot Biginelli reaction coupling of b-ketoesters, aldehydes and urea (or thiourea) to afford the corresponding dihydropyrimidinones/thiones.