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An efficient one-pot multicomponent synthesis of 3,4-dihydropyrimidine-2-(1H)-ones/thiones/imines via a Lewis base catalyzed Biginelli-type reaction under solvent-free conditions

✍ Scribed by Sheik Mansoor, S.; Syed Shafi, S.; Zaheer Ahmed, S.


Book ID
121321957
Publisher
Elsevier
Year
2016
Tongue
English
Weight
499 KB
Volume
9
Category
Article
ISSN
1878-5352

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Gallium(III) Iodide-catalyzed Biginelli-
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## Abstract The Biginelli‐type condensation of ethyl acetoacetate/cycloketone, aldehyde and urea/thiourea under solvent‐free condition catalyzed by 10% gallium(III) iodide to form dihydropyrimidine‐2(1__H__)‐one derivatives was described. This process offered one way to constructing dihydropyrimidi

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We report herein the use of triphenylphosphine (TPP) as a new catalyst for the one-pot Biginelli reaction coupling of b-ketoesters, aldehydes and urea (or thiourea) to afford the corresponding dihydropyrimidinones/thiones.