A one-pot Biginelli synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones catalyzed by triphenylphosphine as Lewis base

✍ Scribed by Abdelmadjid Debache; Mouna Amimour; Ali Belfaitah; Salah Rhouati; Bertrand Carboni

• Book ID: 104095721
• Publisher: Elsevier Science
• Year: 2008
• Tongue: French
• Weight: 163 KB
• Volume: 49
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2008.08.016

✦ Synopsis

We report herein the use of triphenylphosphine (TPP) as a new catalyst for the one-pot Biginelli reaction coupling of b-ketoesters, aldehydes and urea (or thiourea) to afford the corresponding dihydropyrimidinones/thiones.