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An efficient method for the N-debenzylation of aromatic heterocycles

✍ Scribed by Aubrey A. Haddach; Audrey Kelleman; Melissa V. Deaton-Rewolinski

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
71 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

The treatment of N-benzylated heterocycles with potassium tert-butoxide/DMSO and oxygen at room temperature cleanly affords N-debenzylated products in high yield. This procedure can be utilized on a variety of functionalized nitrogen-containing heterocycles such as imidazoles, benzimidazoles, pyrazoles, indazoles, carbazoles, and indoles.

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