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Hydrogenolysis of N-protected aminooxetanes over palladium: An efficient method for a one-step ring opening and debenzylation reaction

✍ Scribed by Ervin Kovács; Angelika Thurner; Ferenc Farkas; Ferenc Faigl; László Hegedűs

Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 220 KB
Volume: 339
Category: Article
ISSN: 1381-1169
DOI: 10.1016/j.molcata.2011.02.008

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✦ Synopsis

An efficient method for the palladium mediated hydrogenation of an optically active, N-protected aminooxetane derivative has been developed. Using appropriate solvents, in a one-step reaction, a chiral 1,4-aminoalcohol derivative [(2S,3R)-4-amino-3-benzoyloxy-2-benzylbutan-1-ol] was formed over a Pd/C catalyst, during hydrogenolytic ring opening and debenzylation reactions.