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An efficient large-scale synthesis of 1H-indazole-[3-14C]carboxylic acid

✍ Scribed by Richard V. Coelho Jr.; Klaas Schildknegt

Publisher
John Wiley and Sons
Year
2007
Tongue
French
Weight
89 KB
Volume
50
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

An efficient large‐scale carbon‐14 synthesis of 1__H__‐indazole‐[3‐^14^C]carboxylic acid starting from [^14^C]potassium cyanide is reported. Key transformations encountered during the synthesis include aromatic nucleophilic substitution of 2‐nitrofluorobenzene by ethyl [^14^C]cyanoacetate, a mild decarbethoxylation and an aniline nitrosation/cyclization. Copyright Β© 2007 John Wiley & Sons, Ltd.

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