An Efficient Dealkylative Addition of Trialkylamines to Dialkyl Acetylenedicarboxylates in the Presence of a Metallic Chloride.
β Scribed by Chan Sik Cho
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 21 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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π SIMILAR VOLUMES
## Abstract Iodine was explored as an efficient catalyst for the synthesis of tetrahydropyrimidines **4** and pyrrolidines **5** by a multicomponent reaction of dialkyl acetylenedicarboxylates (=dialkyl butβ2βynedioates) **1**, amines **2**, and HCHO **3** at room temperature (__Scheme__). When the
The zwitterion, formed from the reaction of an alkyl isocyanide and a dialkyl acetylenedicarboxylate, reacts with phenacyl halides in H 2 O to produce g-iminolactone derivatives in high yields. H 2 O helps to avoid the use of highly toxic and environmentally unfavorable solvents for this conversion.