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Reaction Between Dialkyl Acetylenedicarboxylates and Arylsulfonyl Isocyanates in the Presence of Trialkyl Phosphites: A Simple and Efficient Synthesis of Tetrasubstituted Hydantoins.

✍ Scribed by Abdolali Alizadeh; Hamid R. Bijanzadeh


Publisher
John Wiley and Sons
Year
2005
Weight
18 KB
Volume
36
Category
Article
ISSN
0931-7597

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## Abstract Iodine was explored as an efficient catalyst for the synthesis of tetrahydropyrimidines **4** and pyrrolidines **5** by a multicomponent reaction of dialkyl acetylenedicarboxylates (=dialkyl but‐2‐ynedioates) **1**, amines **2**, and HCHO **3** at room temperature (__Scheme__). When the