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Three-Component Reaction of an Isocyanide and a Dialkyl Acetylenedicarboxylate with a Phenacyl Halide in the Presence of Water: An Efficient Method for the One-Pot Synthesis of γ-Iminolactone Derivatives

✍ Scribed by Ali Ramazani; Aram Rezaei; Amir Tofangchi Mahyari; Morteza Rouhani; Mehdi Khoobi

Publisher
John Wiley and Sons
Year
2010
Tongue
German
Weight
138 KB
Volume
93
Category
Article
ISSN
0018-019X

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✦ Synopsis

The zwitterion, formed from the reaction of an alkyl isocyanide and a dialkyl acetylenedicarboxylate, reacts with phenacyl halides in H 2 O to produce g-iminolactone derivatives in high yields. H 2 O helps to avoid the use of highly toxic and environmentally unfavorable solvents for this conversion.

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✍ Ebrahim Ahmadi; Ali Ramazani; Mehdi Nekomanesh Haghighi 📂 Article 📅 2008 🏛 John Wiley and Sons ⚖ 20 KB 👁 2 views

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