A synthetic route to stable-isotope-substituted L-phenyl-synthesized from both aromatic precursors by initial conversion into sodium phenylpyruvate and subsequent alanine is presented, which allows the introduction of 13 C, 15 N, and deuterium labels at any position or combination of transformation
An efficient chemomicrobiological synthesis of stable isotope-labeled L-tyrosine and L-phenylalanine
β Scribed by Walker, T. E.; Matheny, C.; Storm, C. B.; Hayden, H.
- Book ID
- 127377005
- Publisher
- American Chemical Society
- Year
- 1986
- Tongue
- English
- Weight
- 701 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0022-3263
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Tryptophan synthase catalyzes the nucleophilic replacement of the hydroxyl group at Cβ3 of Lβserine. This enzyme can use benzyl mercaptan as a nucleophile in the conversion of serine to SβbenzylβLβcysteine which is deblocked by treatment with sodium in liquid ammonia to yield Lβcysteine
## Abstract We have developed a stereospecific chemomicrobiological synthesis of labeled tryptophan. Lβ[3β^13^C]Serine, [1β^15^N]β and [2β^13^C]indole were used as precursors for the synthesis of Lβ[Ξ²β^13^C]β, Lβ[1β²β^15^N]β, and Lβ[2β²β^13^C]tryptophan, respectively. The labeled precursors were inco
L-Tyrosine specifically labelled with 13C and 15N has been enzymatically synthesised from achiral precursors in high yield and optical purity.