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An efficient approach to prepare glyoxylyl functionality on solid-support

✍ Scribed by Qingchai Xu; Kit S. Lam

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 71 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)00838-9

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✦ Synopsis

Glyoxylyl group on solid-support is an attractive intermediate for solid-phase synthesis, and combinatorial synthesis. We report here a novel method to generate glyoxylyl functionality on solid-support that involves coupling of acrylic acid, followed by oxidation of the double bond. This highly efficient and versatile approach is compatible with hydroxyl-resins, amino-resins and other solid supports such as glass surfaces.

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