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An Eco-Friendly Asymmetric Organocatalytic Conjugate Addition of Malonates to α,β-Unsaturated Aldehydes: Application on the Synthesis of Chiral Indoles

✍ Scribed by Feu, Karla Santos; Deobald, Anna Maria; Narayanaperumal, Senthil; Corrêa, Arlene G.; Weber Paixão, Márcio


Book ID
120630171
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
597 KB
Volume
2013
Category
Article
ISSN
1434-193X

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Chiral lactones and lactams are endowed with a large spectrum of biological properties [1] including very important pharmaceutical activities. [2] The chiral piperidines (À)paroxetine hydrochloride 1, marketed as paxil/seroxat, and (+)-femoxetine 2 are selective serotonin reuptake inhibitors and are